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Engineered virus-like particles enhance the delivery of prime editor ribonucleoprotein complexes for efficient genomic editing in living systems.

Attaching proteins, nucleic acids, or small molecules to the VLP surface, such as for targeting a specific cell type or for raising an immune response is useful. In some cases a protein of interest can be genetically fused to the viral coat protein. However, this approach sometimes leads to impaired VLP assembly and has limited utility if the targeting agent is not protein-based. An alternative is to assemble the VLP and then use chemical crosslinkers, reactive unnatural amino acids

VLP provides free civil legal services to low income individuals and small not-for-profits in the greater Western New York region. Learn how to get help, volunteer, donate, or find legal clinics on their website.

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